DMPQ:What is YAMANAKA gene? Write down its application

Yamanaka genes are group of four essential genes in our body that are responsible for regenerating old cells or growing new cells.They are also know as OSKM(Oct4,Sox2,Klf4 &Myc) & are named after Japanese scientist Shinya Yamanaka.

Significance of Yamanaka Genes:
Major significance is that the introduction of these genes can convert adult cells into pluripotent stem cells. Pluripotent stems are the cells that can propagate indefinitely & can give rise to different types of cells in body like neurons, heart, pancreatic & liver cells.They are also called as Induced pluripotent stem cells(IPS cells) & can be used to replace damaged or lost cells.

Applications of Yamanaka Genes:
1.Red blood cells: they can be used for RBC generation as type O red blood cells are synthsized from iPSC developed with Yamanaka genes
2.Identification of disease & drug : iPS cells can be derive directly from adult patients & can be used for investigation of diseases and their drugs.
3.Organ synthesis: skin,blood or others cells can be reprogrammed to iPS cells with the help of Yamanka genes and can be used to grow liver cells, neurons etc needed to treat a particular disease.
4.Tissue repair: iPS cells generated from Yamanaka genes can also be used to grow & repair tissues & vascular vessels.

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